業績
英語原著論文
2024
Nosocomial outbreak of SARS-CoV-2 in a hospital ward during the Omicron variant-dominant wave with a review of the relevant literature.
Osaka H, Tagashira Y, Takeuchi H, Tanaka Y, Tanimoto K, Gu Y
Japanese journal of infectious diseases, 10.7883/yoken.JJID.2023.464, 2024
HIV-Tocky system to visualize proviral expression dynamics.
Reda O, Monde K, Sugata K, Rahman A, Sakhor W, Rajib SA, Sithi SN, Tan BJY, Niimura K, Motozono C, Maeda K, Ono M, Takeuchi H, Satou Y
Communications biology, 10.1038/s42003-024-06025-8, 2024
Novel role of host protein SLC25A42 in the HIV-1 reactivation of latent HIV-1 provirus.
Kei Taga, Hiroaki Takeuchi
Microbiology and Immunology, 10.1111/1348-0421.13114, 2024
2023
Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1.
Rosa Mallorson, Eri Miyagi, Sandra Kao, Sayaka Sukegawa, Hideki Saito, Helena Fabryova, Luciana Morellatto Ruggieri, Sonia Mediouni, Susana T Valente, Klaus Strebel
Journal of virology, 10.1128/jvi.01702-23, 2023
Human Mannose Receptor 1 Attenuates HIV-1 Infectivity in a Virus Isolate-Specific Manner.
Hideki Saito, Sayaka Sukegawa, Sandra Kao, Klaus Strebel
Viruses, 10.3390/v15102057, 2023
The possibility of mutations of RAS signaling genes and/or TP53 in combination as a negative prognostic impact on pathological stage I non-small cell lung cancer.
Takayuki Honda, Katsutoshi Seto, Satoshi Endo, Akira Takemoto, Kousuke Tanimoto, Masashi Kobayashi, Masatake Kitano, Rie Sakakibara, Takahiro Mitsumura, Hironori Ishibashi, Johji Inazawa, Toshihiro Tanaka, Yasunari Miyazaki, Kenichi Okubo
Cancer Med, 10.1002/cam4.6535, 2023
Compact wide-field femtoliter-chamber imaging system for high-speed and accurate digital bioanalysis.
Tatsuya Iida, Jun Ando, Hajime Shinoda, Asami Makino, Mami Yoshimura, Kazue Murai, Makiko Mori, Hiroaki Takeuchi, Takeshi Noda, Hiroshi Nishimasu, Rikiya Watanabe
Lab on a Chip, 10.1039/d2lc00741j, 2023
Viral load of SARS-CoV-2 Omicron BA.5 is lower than that of BA.2 despite higher infectivity of BA.5.
Takatsuki Y, Takahashi Y, Nakajima J, Iwasaki Y, Nagano K, Tani-Sassa C, Yuasa S, Kanehira S, Sonobe K, Nukui Y, Takeuchi H, Tanimoto K, Tanaka Y, Kimura A, Ichimura N, Tohda S
Immunity, Inflammation and Disease, 10.1002/iid3.783, 2023
HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.
Fabryova H, Kao S, Sukegawa S, Miyagi E, Taylor L, Ferhadian D, Saito H, Schaal H, Hillebrand F, Strebel K
mBio, 10.1128/mbio.02973-22., 2023
4-phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells.
Haruki Kitamura, Sayaka Sukegawa, Kouki Matsuda, Kousuke Tanimoto, Takuya Kobayakawa, Kazuho Takahashi, Hirokazu Tamamura, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Kenji Maeda, Hiroaki Takeuchi
Biochem Biophys Res Commun, 10.1016/j.bbrc.2022.12.024, 2023
2022
Cholesteatoma has an altered microbiota with a higher abundance of Staphylococcus species.
Taro Fujikawa, Kousuke Tanimoto, Yoshiyuki Kawashima, Taku Ito, Keiji Honda, Takamori Takeda, Akane Sonobe, Natsuki Aoki, Jing Bai, Takeshi Tsutsumi
Laryngoscope Investig Otolaryngol, 10.1002/lio2.934, 2022
Toward the unveiling of HIV-1 dynamics: involvement of monocytes/macrophages in HIV-1 infection.
Sayaka Sukegawa, Hiroaki Takeuchi
Frontiers in Virology, 10.3389/fviro.2022.934892, 2022
Viral load of SARS-CoV-2 Omicron is not high despite its high infectivity.
Yuasa Sonoka, Nakajima Jun, Takatsuki Yuna, Takahashi Yuta, Tani-Sassa Chihiro, Iwasaki Yumi, Nagano Katsutoshi, Sonobe Kazunari, Yoshimoto Tomoyo, Nukui Yoko, Takeuchi Hiroaki, Tanimoto Kousuke, Tanaka Yukie, Kimura Akinori, Ichimura Naoya, Tohda Shuji
JOURNAL OF MEDICAL VIROLOGY, 10.1002/jmv.27974, 2022
Maternal embryonic leucine zipper kinase (MELK) optimally regulates the HIV-1 uncoating process.
Nishiyama Takara, Takada Toru, Takeuchi Hiroaki, Iwami Shingo
JOURNAL OF THEORETICAL BIOLOGY, 10.1016/j.jtbi.2022.111152, 2022
The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter.
Kao S, Miyagi E, Mallorson R, Saito H, Sukegawa S, Mukherji A, Mateja A, Ferhadian D, Fabryova H, Clouse K, Strebel K
Journal of Virology, 10.1128/jvi.00652-22., 2022
Evaluation of the Geenius HIV 1/2 confirmatory assay for HIV-2 samples isolated in Japan.
Shigemi U, Yamamura Y, Matsuda M, Okazaki R, Kubota M, Ibe S, Nemoto M, Maejima-Kitagawa M, Sukegawa S, Imahashi M, Kikuchi T, Sugiura W, Iwatani Y, Hachiya A, Yokomaku Y;
Journal of clinical virology, 10.1016/j.jcv.2022.105189., 2022
Automated amplification-free digital RNA detection platform for rapid and sensitive SARS-CoV-2 diagnosis.
Shinoda Hajime, Iida Tatsuya, Makino Asami, Yoshimura Mami, Ishikawa Junichiro, Ando Jun, Murai Kazue, Sugiyama Katsumi, Muramoto Yukiko, Nakano Masahiro, Kiga Kotaro, Cui Longzhu, Nureki Osamu, Takeuchi Hiroaki, Noda Takeshi, Nishimasu Hiroshi, Watanabe Rikiya
COMMUNICATIONS BIOLOGY, 10.1038/s42003-022-03433-6, 2022
Methodology to Detect Biological Particles Using a Biosensing Surface Integrated in Resistive Pulse Sensing.
Horiguchi Yukichi, Naono Norihiko, Sakamoto Osamu, Takeuchi Hiroaki, Yamaoka Shoji, Miyahara Yuji
ACS APPLIED MATERIALS & INTERFACES, 10.1021/acsami.1c25006, 2022
Pathogenic variant of RBM20 in a multiplex family with hypertrophic cardiomyopathy.
Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Hisanori Kosuge, Shinji Suzuki, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura
Hum Genome Var, 10.1038/s41439-022-00183-z, 2022
Flavivirus recruits the valosin-containing protein (VCP)/NPL4 complex to induce stress granule disassembly for efficient viral genome replication.
Arakawa M, Tabata K, Ishida K, Kobayashi M, Arai A, Ishikawa T, Suzuki R, Takeuchi H, Tripathi LP, Mizuguchi K, Morita E
The Journal of biological chemistry, 10.1016/j.jbc.2022.101597, 2022
2021
Viral loads and profile of the patients infected with SARS-CoV-2 Delta, Alpha, or R.1 variants in Tokyo.
Tani-Sassa Chihiro, Iwasaki Yumi, Ichimura Naoya, Nagano Katsutoshi, Takatsuki Yuna, Yuasa Sonoka, Takahashi Yuta, Nakajima Jun, Sonobe Kazunari, Nukui Yoko, Takeuchi Hiroaki, Tanimoto Kousuke, Tanaka Yukie, Kimura Akinori, Tohda Shuji
JOURNAL OF MEDICAL VIROLOGY, 10.1002/jmv.27479, 2021
Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan.
Oba Seiya, Hosoya Tadashi, Amamiya Miki, Mitsumura Takahiro, Kawata Daisuke, Sasaki Hirokazu, Kamiya Mari, Yamamoto Akio, Ando Takahiro, Shimada Sho, Shirai Tsuyoshi, Okamoto Tsukasa, Tateishi Tomoya, Endo Akira, Aiboshi Junichi, Nosaka Nobuyuki, Yamanouchi Hideo, Ugawa Toyomu, Nagaoka Eiki, Oi Keiji, Tao Susumu, Maejima Yasuhiro, Tanaka Yukie, Tanimoto Kousuke, Takeuchi Hiroaki, Tohda Shuji, Hirakawa Akihiro, Sasano Tetsuo, Arai Hirokuni, Otomo Yasuhiro, Miyazaki Yasunari, Yasuda Shinsuke
FRONTIERS IN CARDIOVASCULAR MEDICINE, 10.3389/fcvm.2021.767074, 2021
A new in-vitro model to monitor HIV-1 proviral transcription by timer-fluorescence protein.
Reda O, Monde K, Sugata K, Rahman A, Sakhor W, Tan B J, Matsuo M, Takeuchi H, Ono M, Satou Y
HIV MEDICINE, , 2021
Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells.
Chang Liu, Yasuyuki Gen, Kousuke Tanimoto, Tomoki Muramatsu, Jun Inoue, Johji Inazawa
Mol Ther Nucleic Acids, 10.1016/j.omtn.2021.05.001, 2021
Identification and characterization of Stathmin 1 as a host factor involved in HIV-1 latency.
Deletsu Selase D, Kitamura Haruki, Ishida Takaomi, Gohda Jin, Yamaoka Shoji, Takeuchi Hiroaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 10.1016/j.bbrc.2021.06.017, 2021
SARS-CoV-2 R.1 lineage variants that prevailed in Tokyo in March 2021.
Nagano Katsutoshi, Tani-Sassa Chihiro, Iwasaki Yumi, Takatsuki Yuna, Yuasa Sonoka, Takahashi Yuta, Nakajima Jun, Sonobe Kazunari, Ichimura Naoya, Nukui Yoko, Takeuchi Hiroaki, Tanimoto Kousuke, Tanaka Yukie, Kimura Akinori, Tohda Shuji
JOURNAL OF MEDICAL VIROLOGY, 10.1002/jmv.27240, 2021
Integrative genome-wide analyses reveal the transcriptional aberrations in Japanese esophageal squamous cell carcinoma.
Akira Takemoto, Kousuke Tanimoto, Seiichi Mori, Jun Inoue, Naoto Fujiwara, Tetsuo Noda, Johji Inazawa
Cancer Science, 10.1111/cas.15063, 2021
Development and evaluation of a rapid and cost-efficient NGS-based MHC class I genotyping method for macaques by using a prevalent short-read sequencer.
Kousuke Tanimoto, Taeko K Naruse, Tetsuro Matano, Akinori Kimura
Immunogenetics, 10.1007/s00251-020-01199-x, 2021
[Genomics and epidemiology of SARS-CoV-2 lineage].
Sukegawa S, Takeuchi H
Uirusu, 10.2222/jsv.71.19, 2021
2020
M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms.
Lotfi S, Nasser H, Noyori O, Hiyoshi M, Takeuchi H, Koyanagi Y, Suzu S
Retrovirology, 10.1186/s12977-020-00528-y, 2020
miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway.
Takagawa Yuki, Gen Yasuyuki, Muramatsu Tomoki, Tanimoto Kousuke, Inoue Jun, Harada Hiroyuki, Inazawa Johji
MOLECULAR THERAPY, 10.1016/j.ymthe.2020.04.001, 2020
Inhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor Beta.
Eri Miyagi, Sarah Welbourn, Sayaka Sukegawa, Helena Fabryova, Sandra Kao, Klaus Strebel
J Virol, 10.1128/JVI.01708-19, 2020
ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.
Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh
Life Science Alliance, 10.26508/lsa.201900576, 2020
Vpu of a Simian Immunodeficiency Virus Isolated from Greater Spot-Nosed Monkey Antagonizes Human BST-2 via Two AxxxxxxxW Motifs.
Weitong Yao, Takeshi Yoshida, Saki Hashimoto, Hiroaki Takeuchi, Klaus Strebel, Shoji Yamaoka
J. Virol., 10.1128/JVI.01669-19, 2020
2019
Genome-wide RNAi screen identifies MAPK-RPK required for HIV-1 proviral silencing in non-T cell reservoir cell-line model.
H Takeuchi, T Ishida, Y Satou, J Gohda, H Kitamura, S Gan, K Takahashi, S Yamaoka
Journal of Virus Eradication, 10.1016/S2055-6640(20)30081-9, 2019
Massive computational identification of somatic variants in exonic splicing enhancers using The Cancer Genome Atlas.
Kousuke Tanimoto, Tomoki Muramatsu, Johji Inazawa
Cancer Med, 10.1002/cam4.2619, 2019
HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus.
Iwase CS, Miyazato P, Katsuya H, Islam S, Yang TJS, Ito J, Matsuo M, Takeuchi H, Ishida T, Matsuda K, Maeda K, Satou Y
Scientific Reports, 10.1038/s41598-019-48681-5., 2019
Discovery and Development of anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication.
Maeda K, Das D, Kobayakawa T, Tamamura H, Takeuchi H
Current Topics in Medicinal Chemistry, 10.2174/1568026619666190712204603., 2019
PATZ1 is required for efficient HIV-1 infection.
Aziati ID, Yoshida T, Hamano A, Maeda K, Takeuchi H, Yamaoka S
Biochemical and biophysical research communications, 10.1016/j.bbrc.2019.04.175, 2019
Discovery of 4-oxoquinolines, a new chemical class of anti-HIV-1 compounds.
Shiroishi-Wakatsuki T, Maejima-Kitagawa M, Hamano A, Murata D, Sukegawa S, Matsuoka K, Ode H, Hachiya A, Imahashi M, Yokomaku Y, Nomura N, Sugiura W, Iwatani Y
Antiviral Research, 2019
2018
Robust Enhancement of Lentivirus Production by Promoter Activation.
Suzuki N, Yoshida T, Takeuchi H, Sakuma R, Sukegawa S, Yamaoka S
Scientific Reports, 2018
Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages.
Siddiqui R, Suzu S, Ueno M, Nasser H, Koba R, Bhuyan F, Noyori O, Hamidi S, Sheng G, Yasuda-Inoue M, Hishiki T, Sukegawa S, Miyagi E, Strebel K, Matsushita S, Shimotohno K, Ariumi Y
PLoS Pathogen, 2018
HIV-1 Vpr and p21 restrict LINE-1 mobility.
Kawano K, Doucet AJ, Ueno M, Kariya R, An W, Marzetta F, Kuroki M, Turelli P, Sukegawa S, Okada S, Strebel K, Trono D, Ariumi Y
Nucleic Acids Research, 2018
Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction.
Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura
J. Hum. Genet., 10.1038/s10038-018-0509-9, 2018
Gold Nanoparticles with Ligand/Zwitterion Hybrid Layer for Individual Counting of Influenza A H1N1 Subtype Using Resistive Pulse Sensing.
Yukichi Horiguchi, Tatsuro Goda, Akira Matsumoto, Hiroaki Takeuchi, Shoji Yamaoka, Yuji Miyahara
Langmuir, 10.1021/acs.langmuir.8b01586, 2018
Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy.
Takeharu Hayashi, Kousuke Tanimoto, Kayoko Hirayama-Yamada, Etsuko Tsuda, Mamoru Ayusawa, Shinichi Nunoda, Akira Hosaki, Akinori Kimura
J. Hum. Genet., 10.1038/s10038-018-0479-y, 2018
eIF4A2 is a host factor required for efficient HIV-1 replication.
Jerry Kwame Ndzinu, Hiroaki Takeuchi, Hideki Saito, Takeshi Yoshida, Shoji Yamaoka
Microbes Infect., 10.1016/j.micinf.2018.05.001, 2018
Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors.
Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers
Blood, 10.1182/blood-2017-09-805259, 2018
miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein.
Tonouchi E, Gen Y, Muramatsu T, Hiramoto H, Tanimoto K, Inoue J, Inazawa J
Scientific reports, 10.1038/s41598-018-22767-y, 2018
BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1.
Jin Gohda, Kazuo Suzuki, Kai Liu, Xialin Xie, Hiroaki Takeuchi, Jun-Ichiro Inoue, Yasushi Kawaguchi, Takaomi Ishida
Sci Rep, 10.1038/s41598-018-21942-5, 2018
A20 restores phorbol ester-induced differentiation of THP-1 cells in the absence of nuclear factor-κB activation.
Osako M, Itsumi M, Yamaguchi H, Takeuchi H, Yamaoka S
Journal of Cellular Biochemistry, 10.1002/jcb.26308, 2018
Human Influenza Virus Detection Using Sialyllactose-Functionalized Organic Electrochemical Transistors.
Hai W, Goda T, Takeuchi H, Yamaoka S, Horiguchi Y, Matsumoto A, Miyahara Y
Sensors & Actuators B-Chemical, 2018
Mannose Receptor 1 Restricts HIV Particle Release from Infected Macrophages.
Sukegawa S, Miyagi E, Bouamr F, Fabryova H, Strebel K
Cell Reports., 10.1016/j.celrep.2017.12.085, 2018
2017
Human SMOOTHENED inhibits human immunodeficiency virus type 1 infection.
Takeshi Yoshida, Akiko Hamano, Asuka Ueda, Hiroaki Takeuchi, Shoji Yamaoka
Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2017.09.063, 2017
N-terminally truncated POM121C inhibits HIV-1 replication.
Hideki Saito, Hiroaki Takeuchi, Takao Masuda, Takeshi Noda, Shoji Yamaoka
PLoS ONE, 10.1371/journal.pone.0182434, 2017
Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH).
Shin Hayashi, Daniela Tiaki Uehara, Kousuke Tanimoto, Seiji Mizuno, Yasutsugu Chinen, Shinobu Fukumura, Jun-Ichi Takanashi, Hitoshi Osaka, Nobuhiko Okamoto, Johji Inazawa
PLoS ONE, 10.1371/journal.pone.0181791, 2017
Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis.
Hiroaki Takeuchi, Hideki Saito, Takeshi Noda, Tadashi Miyamoto, Tomokazu Yoshinaga, Kazutaka Terahara, Hiroshi Ishii, Yasuko Tsunetsugu-Yokota, Shoji Yamaoka
PLoS Pathog, 10.1371/journal.ppat.1006441, 2017
Direct and label-free influenza virus detection based on multisite binding to sialic acid receptors.
Yukichi Horiguchi, Tatsuro Goda, Akira Matsumoto, Hiroaki Takeuchi, Shoji Yamaoka, Yuji Miyahara
Biosens Bioelectron, 10.1016/j.bios.2017.02.023, 2017
Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma.
Hiroaki Nagata, Ken-Ichi Kozaki, Tomoki Muramatsu, Hidekazu Hiramoto, Kousuke Tanimoto, Naoto Fujiwara, Seiya Imoto, Daisuke Ichikawa, Eigo Otsuji, Satoru Miyano, Tatsuyuki Kawano, Johji Inazawa
Oncotarget, 10.18632/oncotarget.17147, 2017
miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer.
Hidekazu Hiramoto, Tomoki Muramatsu, Daisuke Ichikawa, Kousuke Tanimoto, Satoru Yasukawa, Eigo Otsuji, Johji Inazawa
Sci Rep, 10.1038/s41598-017-04191-w, 2017
Specific Recognition of Human Influenza Virus with PEDOT Bearing Sialic Acid-Terminated Trisaccharides.
Wenfeng H, Goda T, Takeuchi H, Yamaoka S, Horiguchi Y, Akira M, Miyahara Y
ACS Applied Materials & Interfaces, 10.1021/acsami.7b02523, 2017
Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma.
Yu Oikawa, Kei-Ichi Morita, Kou Kayamori, Kousuke Tanimoto, Kei Sakamoto, Hiroto Katoh, Shumpei Ishikawa, Johji Inazawa, Hiroyuki Harada
Cancer Sci., 10.1111/cas.13126, 2017
2016
CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IRE1α and PERK.
Daisuke Kikuchi, Kousuke Tanimoto, Koh Nakayama
Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2015.11.113, 2016
2015
Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.
Mai Nanya, Masaki Sato, Kousuke Tanimoto, Minoru Tozuka, Shuki Mizutani, Masatoshi Takagi
PLoS ONE, 10.1371/journal.pone.0144540, 2015
Simultaneous Detection of Both Single Nucleotide Variations and Copy Number Alterations by Next-Generation Sequencing in Gorlin Syndrome.
Kei-ichi Morita, Takuya Naruto, Kousuke Tanimoto, Chisato Yasukawa, Yu Oikawa, Kiyoshi Masuda, Issei Imoto, Johji Inazawa, Ken Omura, Hiroyuki Harada
PLoS ONE, 10.1371/journal.pone.0140480, 2015
miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity.
Naoto Fujiwara, Jun Inoue, Tatsuyuki Kawano, Kousuke Tanimoto, Ken-Ichi Kozaki, Johji Inazawa
Cancer Res., 10.1158/0008-5472.CAN-15-0257, 2015
2014以前
Suppressor of cytokine signaling 1 counteracts rhesus macaque TRIM5α-induced inhibition of human immunodeficiency virus type-1 production.
Sukegawa S, Sakuma R, Ohmine S, Takeuchi H, Ikeda Y, Yamaoka S
PLoS One, 10.1371/journal.pone.0109640, 2014
Screening for possible miRNA-mRNA associations in a colon cancer cell line.
Sotaro Kanematsu, Kousuke Tanimoto, Yutaka Suzuki, Sumio Sugano
Gene, 533(2)520-531, 10.1016/j.gene.2013.08.005, 2014
Induction of heat-shock protein 70 by prostaglandin A1 inhibits HIV-1 Vif-mediated degradation of APOBEC3G.
Sugiyama R, Abe M, Nishitsuji H, Murakami Y, Takeuchi H, Takaku H
Antiviral Research, 99(3)307-311, , 2013
A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly.
Takanori Hori, Hiroaki Takeuchi, Hideki Saito, Ryuta Sakuma, Yoshio Inagaki, Shoji Yamaoka
J. Virol., 87(13)7726-7736, 10.1128/JVI.00124-13, 2013
The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma.
Mayuko Furuta, Ken-ichi Kozaki, Kousuke Tanimoto, Shinji Tanaka, Shigeki Arii, Teppei Shimamura, Atsushi Niida, Satoru Miyano, Johji Inazawa
PLoS ONE, 8(3)e60155, 10.1371/journal.pone.0060155, 2013
SIV replication in human cells.
Ryuta Sakuma, Hiroaki Takeuchi
Front Microbiol, 10.3389/fmicb.2012.00162, 2012
Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication.
Hiroaki Takeuchi, Hiroshi Ishii, Tetsuya Kuwano, Natsuko Inagaki, Hirofumi Akari, Tetsuro Matano
Retrovirology, 10.1186/1742-4690-9-3, 2012
Characterization of STAT6 target genes in human B cells and lung epithelial cells.
Akinori Kanai, Kenta Suzuki, Kousuke Tanimoto, Junko Mizushima-Sugano, Yutaka Suzuki, Sumio Sugano
DNA Res., 18(5)379-392, 10.1093/dnares/dsr025, 2011
Genome-wide characterization of transcriptional start sites in humans by integrative transcriptome analysis.
Riu Yamashita, Nuankanya P Sathira, Akinori Kanai, Kousuke Tanimoto, Takako Arauchi, Yoshiaki Tanaka, Shin-Ichi Hashimoto, Sumio Sugano, Kenta Nakai, Yutaka Suzuki
Genome Res., 21(5)775-789, 10.1101/gr.110254.110, 2011
Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G.
Sugiyama R, Nishitsuji H, Furukawa A, Katahira M, Habu Y, Takeuchi H, Ryo A, Takaku H
Journal of Biological Chemistry, 286(12)10051-10057, , 2011
The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production.
Ohmine S, Sakuma R, Sakuma T, Thatava T, Takeuchi H, Ikeda Y
PLoS ONE, 6(1)e16121, , 2011
Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing.
Kousuke Tanimoto, Katsuya Tsuchihara, Akinori Kanai, Takako Arauchi, Hiroyasu Esumi, Yutaka Suzuki, Sumio Sugano
Hugo J, 4(1-4)35-48, 10.1007/s11568-011-9150-9, 2010
Characterization of transcription start sites of putative non-coding RNAs by multifaceted use of massively paralleled sequencer.
Nuankanya Sathira, Riu Yamashita, Kousuke Tanimoto, Akinori Kanai, Takako Arauchi, Soutaro Kanematsu, Kenta Nakai, Yutaka Suzuki, Sumio Sugano
DNA Res., 17(3)169-183, 10.1093/dnares/dsq007, 2010
Contribution of Cyclophilin A to determination of simian immunodeficiency virus tropism: a progress update.
Hiroaki Takeuchi
Vaccine, 10.1016/j.vaccine.2009.10.020, 2010
Broadening of CD8+ cell responses in vaccine-based simian immunodeficiency virus controllers.
Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T
AIDS, 24(18)2777-2787, , 2010
A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins.
Inagaki N, Takeuchi H, Yokoyama M, Sato H, Ryo A, Yamamoto H, Kawada M, Matano T
Retrovirology, 2010
Massive transcriptional start site analysis of human genes in hypoxia cells.
Katsuya Tsuchihara, Yutaka Suzuki, Hiroyuki Wakaguri, Takuma Irie, Kousuke Tanimoto, Shin-ichi Hashimoto, Kouji Matsushima, Junko Mizushima-Sugano, Riu Yamashita, Kenta Nakai, David Bentley, Hiroyasu Esumi, Sumio Sugano
Nucleic Acids Res., 37(7)2249-2263, 10.1093/nar/gkp066, 2009
Host factors involved in resistance to retroviral infection.
Hiroaki Takeuchi, Tetsuro Matano
Microbiol. Immunol., 52(6)318-325, 10.1111/j.1348-0421.2008.00040.x, 2008
Gag-specific cytotoxic T-lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial.
Kawada M, Tsukamoto T, Yamamoto H, Iwamoto N, Kurihara K, Takeda A, Moriya C, Takeuchi H, Akari H, Matano T
Journal of Virology, 82(20)10199-10206, , 2008
HIV-1 Vif promotes the formation of high molecular mass APOBEC3G complexes.
Goila-Gaur R, Khan MA, Miyagi E, Kao S, Opi S, Takeuchi H, Strebel K
Virology, 372(1)136-146, , 2008
Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells.
Hiroaki Takeuchi, Alicia Buckler-White, Ritu Goila-Gaur, Eri Miyagi, Mohammad A Khan, Sandrine Opi, Sandra Kao, Elena Sokolskaja, Thomas Pertel, Jeremy Luban, Klaus Strebel
J. Virol., 81(15)8080-8090, 10.1128/JVI.02727-06, 2007
Enzymatically Active APOBEC3G Is required for Efficient Inhibition of HIV-1.
Miyagi E, Opi S, Takeuchi H, Khan MA, Goila-Gaur R, Kao S, Strebel K
Journal of Virology, 81(24)13346-13353, , 2007
Production of infectious virus and degradation of APOBEC3G are separable functional properties of human immunodeficiency virus type 1 Vif.
Kao S, Goila-Gaur R, Miyagi E, Kahn MA, Opi S, Takeuchi H, Strebel K
Virology, 369(2)329-339, 2007
Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variant.
Opi S, Kao S, Goila-Gaur R, Khan MA, Miyagi E, Takeuchi H, Strebel K
Journal of Virology, 81(15)8236-8246, , 2007
Analysis of the contribution of cellular and viral RNA to the packaging of APOBEC3G into HIV-1 virions.
Khan MA, Goila-Gaur R, Opi S, Miyagi E, Takeuchi H, Kao S, Strebel K
Retrovirology, 4(1)48, , 2007
Biochemical activities of highly purified, catalytically active human APOBEC3G: correlation with antiviral effect.
Iwatani Y, Takeuchi H, Strebel K, Levin JG
Journal of Virology, 80(12)5992-6002, , 2006
Anti-V3 Humanized Antibody KD-247 Effectively Suppresses Ex Vivo Generation of Human Immunodeficiency Virus Type 1 and Affords Sterile Protection of Monkeys against a Heterologous Simian/Human Immunodeficiency Virus Infection.
Eda Y, Murakami T, Ami Y, Nakasone T, Takizawa M, Someya K, Kaizu M, Izumi Y, Yoshino N, Matsushita S, Higuchi H, Matsui H, Shinohara K, Takeuchi H, Koyanagi Y, Yamamoto N, Honda M
Journal of Virology, 80(11)5563-5570, , 2006
Monomeric APOBEC3G is catalytically active and has antiviral activity.
Opi S, Takeuchi H, Kao S, Khan MA, Miyagi E, Goila-Gaur R, Iwatani Y, Levin LG, Strebel K
Journal of Virology, 80(10)4673-4682, , 2006
Production of infectious SIVagm from human cells requires functional inactivation but not viral exclusion of human APOBEC3G.
Hiroaki Takeuchi, Sandra Kao, Eri Miyagi, Mohammad A Khan, Alicia Buckler-White, Ron Plishka, Klaus Strebel
J. Biol. Chem., 280(1)375-382, 10.1074/jbc.M408987200, 2005
Suppression of human immunodeficiency virus type 1 (HIV-1) replication by an HIV-1-dependent double locked vector with the Cre/loxP system.
Habu Y, Nagawa T, Matsumoto N, Takeuchi H, Miyano-Kurosaki N, Takaku H
Nucleosides Nucleotides Nucleic Acids, 24(10-12)1907-1917, , 2005
Viral RNA is required for the Association of APOBEC3G with HIV-1 Nucleoprotein Complexes.
Khan MA, Kao S, Miyagi E, Takeuchi H, Goila-Gaur R, Opi S, Gipson CL, Parslow TG, Ly H, Strebel K
Journal of Virology, 79(9)5870-5874, , 2005
Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells.
Kao S, Miyagi E, Khan MA, Takeuchi H, Opi S, Goila-Gaur R, Strebel K
Retrovirology, 1(1)27, , 2004
In vitro and in vivo transport and delivery of phosphorothioate oligonucleotides with cationic liposomes.
Miyano-Kurosaki N, Barnor JS, Takeuchi H, Owada T, Nakashima H, Yamamoto N, Matsuzaki T, Shimada F, Takaku H
Antiviral Chemistry and Chemotherapy, 15(2)93-100, , 2004
Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2’-O-methyl-guanosine-uridine quadruplex motifs.
Kuwasaki T, Hatta M, Takeuchi H, Takaku H
Journal of Antimicrobial Chemotherapy, 51(4)813-819, , 2003
Isolation and characterization of an infectious HIV type 1 molecular clone from a patient with primary infection.
Hiroaki Takeuchi, Youichi Suzuki, Masashi Tatsumi, Hiroo Hoshino, Eric S Daar, Yoshio Koyanagi
AIDS Res. Hum. Retroviruses, 18(15)1127-1133, 10.1089/088922202320567860, 2002
Inhibition of HIV-1 replication by an HIV-1 dependent ribozyme expression vector with the Cre/loxP (ON/OFF) system.
Habu Y, Miyano-Kurosaki N, Nagawa T, Matsumoto N, Takeuchi H, Takaku H
Antiviral Chemistry and Chemotherapy, 13(5)273-281, , 2002
Inhibition of Human Immunodeficiency Virus Type-1 replication by P-stereodefined oligo (nucleoside phosphorothioate)s in a long-term infection model.
Inagawa T, Nakashima H, Karwowski B, Guga P, Stec WJ, Takeuchi H, Takaku H
FEBS Letter , , 528(1-3)48-52, 2002
Development of HIV-1 dependent gene expression vector with the Cre/loxP (ON) system.
Nagawa T, Habu Y, Matsumoto N, Takeuchi H, Miyano-Kurosaki N, Takaku H
Nucleic Acids Resarch, 2002
RNA cleavage by a mammalian tRNA 3’ processing endoribonuclease (3’tRNase) reduces HIV-1 expression.
Yukita M, Kitano M, Miyano-Kurosaki N, Takeuchi H, Nashimoto M, Takaku H
Nucleic Acids Resarch, 2002
Inhibition of human immunodeficiency virus type 1 activity in vitro by a new self-stabilized oligonucleotide with guanosine-thymidine quadruplex motifs.
Suzuki J, Miyano-Kurosaki N, Kuwasaki T, Takeuchi H, Kawai G, Takaku H
Journal of Virology, 2002
Inhibition of HIV-1 replication by the Cre-loxP hammerhead ribozyme.
Habu Y, Miyano-Kurosaki N, Takeuchi H, Matsumoto N, Tamura Y, Takaku H
Nucleosides Nucleotides Nucleic Acids, 20(4-7)723-726, , 2001
Effective suppression of HIV-1 gene expression by a mammalian tRNA 3’ processing endoribonuclease and external guide sequence oligozymes.
Kitano M, Barnor JS, Miyano-Kurosaki N, Endo Y, Yukita M, Takeuchi H, Tamura Y, Takai K, Nashimoto M, Takaku H
Nucleosides Nucleotides Nucleic Acids, 20(4-7)719-722, , 2001
Effective suppression of HIV-1 gene expression by a mammalian tRNA 3’ processing endoribonuclease and external guide sequence oligozymes.
Kitano M, Miyano-Kurosaki N, Endo Y, Yukita M, Takeuchi H, Tamura Y, Takai K, Nashimoto M, Takaku H
Nucleic Acids Symposium Series, 1999
Development of an HIV-1-dependent expression vector with the Cre/loxP system.
Habu Y, Takeuchi H, Tamura Y, Miyano-Kurosaki N, Takai K, Takaku H
Nucleic Acids Symposium Series, 1999
Phosphorothioate G3T4G3 motifs inhibit the early stage of HIV-1 infection.
Suzuki J, Miyano-Kurosaki N, Takeuchi H, Tamura Y, Kawai G, Takai K, Tanaka Y, Tanaka R, Yamamoto N, Takaku H
Nucleic Acids Symposium Series, 1999
Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides.
Hosoya T, Takeuchi H, Kanesaka Y, Yamakawa H, Miyano-Kurosaki N, Takai K, Yamamoto N, Takaku H
FEBS Letters, 19(461 (3))136-140, 1999
Inhibition of gene expression by oligonucleotides forming triple-helices with the polypurine tract of HIV-1.
Tsukahara S, Suzuki J, Goto Y, Inagawa T, Takeuchi H, Takai K, Koyanagi Y, Yamamoto N, Takaku H
Nucleic Acids Symposium Series, 1996
日本語原著論文
2022
【コロナ感染症の後遺症】COVID-19免疫の展望.
北村 義浩, 武内 寛明, 俣野 哲朗
カレントテラピー, 2022
【新型コロナウイルス感染症(COVID-19)のすべて】病態と診断 SARS-CoV-2変異ウイルス 突然変異と選択から見えてくる進化の方向性.
武内 寛明
呼吸器ジャーナル, 2022
2021
【新型コロナウイルス感染症(COVID-19)対策のこれから-ワクチンを中心に】COVID-19パンデミック下のSARS-CoV-2変異株の特徴および本邦市中流行株の遷移.
北村 春樹, 多賀 佳, 助川 明香, 武内 寛明
臨床と微生物, 2021
COVID-19パンデミック下のSARS-CoV-2変異株の特徴および本邦市中流行株の遷移.
北村春樹、多賀佳、助川明香、武内寛明
臨床と微生物, 2021
COVID-19パンデミック下のSARS-CoV-2変異株の特徴および日本における市中流行株の遷移.
助川 明香、武内 寛明
日本ウイルス学会誌「ウイルス」, 2021
2020
HIV学術研究の今「ウイルスと宿主とのせめぎ合いから」(複製および病原性) ウイルスの宿主適応メカニズム 宿主防御機構とのせめぎ合いと攻略能獲得まで.
芳田 剛, Yao Weitong, 橋本 紗希, 武内 寛明, 山岡 昇司
日本エイズ学会誌, 2020
HIV機能的治癒に向けた取り組みの現状 潜伏HIVリザーバー維持メカニズム 感染細胞レベルからその要因を解く リザーバー特異的排除戦略によるHIV寛解をめざして.
武内 寛明
日本エイズ学会誌, 2020
2019
HIV-1は抗ウイルスタンパク質ヒトBST-2を妨害する機能をどのように獲得したのか.
Yao Weitong, 芳田 剛, 橋本 紗希, 武内 寛明, 山岡 昇司
日本エイズ学会誌, 2019
分子認識とAIを活用したヒトインフルエンザウイルス粒子測定.
堀口 諭吉, 直野 典彦, 坂本 修, 武内 寛明, 山岡 昇司, 谷口 正輝, 鷲尾 隆, 宮原 裕二
日本バイオマテリアル学会大会予稿集, 2019
分子認識界面とAIテクノロジーを応用したウイルス粒子計測技術の創出.
堀口 諭吉, 直野 典彦, 坂本 修, 武内 寛明, 山岡 昇司, 谷口 正輝, 鷲尾 隆, 宮原 裕二
日本分析化学会講演要旨集, 2019
ヒト以外の動物種を対象としたNGSによるMHCタイピング法.
谷本 幸介, 成瀬 妙子, 木村 彰方
MHC, 10.12667/mhc.26.115, 2019
2018
HIV潜伏感染を制御する宿主因子の同定および解析.
武内 寛明, 合田 仁, 石田 尚臣, 佐藤 賢文, 岩瀬 早織, 山岡 昇司
日本エイズ学会誌, 2018
HIV感染に必要な細胞因子スクリーニングのためのジフテリア毒素とGFPのデュアルスプリットタンパク質の構築.
合田 仁, 武内 寛明, 石田 尚臣
日本エイズ学会誌, 2018
細孔電気抵抗法を用いたヒトインフルエンザウイルスの特異的検出.
堀口 諭吉, 合田 達郎, 松元 亮, 武内 寛明, 山岡 昇司, 宮原 裕二
日本分析化学会講演要旨集, 2018
新規HIV-1感染制御宿主因子の同定およびその機能解明.
武内 寛明
日本エイズ学会誌, 2018
Identification of a host factor supporting HIV-1 entry(和訳中).
Yoshida Takeshi, Kawamura Saki, Yamaguchi Haruka, Takeuchi Hiroaki, Yamaoka Shoji
日本エイズ学会誌, 2018
2017
ウイルス認識ナノ粒子を用いた電気抵抗ナノパルス法によるウイルス計測.
堀口 諭吉, 合田 達郎, 松元 亮, 武内 寛明, 山岡 昇司, 宮原 裕二
日本バイオマテリアル学会大会予稿集, 2017
コア・サイエンス HIV-1コア・サイエンス HIV-1コア(キャプシドコア)崩壊プロセスおよびHIV-1複合体コア(核)移行プロセスのさらなる展望.
武内 寛明
日本エイズ学会誌, 2017
HIV-1の祖先ウイルスが発現するVpuタンパク質の機能における種特異性とそのメカニズム.
Hashimoto Saki, Yoshida Takeshi, Takeuchi Hiroaki, Yamaoka Shoji
日本エイズ学会誌, 2017